Large study broadens view of the genetic landscape of bipolar disorder
Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00101-7A multi-ancestry genome-wide study of 158,036 people with bipolar disorder and 2,796,499 control individuals identified 298 genomic regions associated with the disease. Variations in 36 genes were linked to the condition, and this variation was enriched in certain neuronal cell populations. The genetic architecture underlying bipolar disorder varied with subtype and how cases were identified.
Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00101-7A multi-ancestry genome-wide study of 158,036 people with bipolar disorder and 2,796,499 control individuals identified 298 genomic regions associated with the disease. Variations in 36 genes were linked to the condition, and this variation was enriched in certain neuronal cell populations. The genetic architecture underlying bipolar disorder varied with subtype and how cases were identified.
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